KLK 11 ( Kallikrein - related peptidase 11 )
نویسندگان
چکیده
Three alternatively spliced variants have been described in the literature: including isoform 1, isoform 2, and isoform 3. Isoform 1 is preferentially expressed in the brain and it encodes a protein of 250 amino acids. Isoform 2 and isoform 3 are mainly expressed in the prostate. Compared to isoform 1, isoform 2 has additional 32 amino acids at the N-terminus and isoform 3 contains extra 25 amino acids inserted in the catalytic triad. Tissue-specific expression of these isoforms is regulated by multiple promoters that locate in the first exon of each isoform.
منابع مشابه
Regulation of human tissue kallikrein-related peptidase expression by steroid hormones in 32 cell lines.
Human tissue kallikrein-related peptidases(KLK), which are secreted serine proteases, are encoded by 15 genes located on chromosome 19q 13.4. Previous studies have shown that KLK expression is regulated by steroid hormones and many KLKs are dysregulated in hormone dependent malignancies. Some KLKs are proposed biomarkers for these cancers. We have characterized KLK hormonal regulation patterns ...
متن کاملTissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function.
Abstract Tissue kallikrein (kallikrein 1) was first identified in pancreas and is the namesake of the kallikrein-related peptidase (KLK) family. KLK1 and the other 14 members of the human KLK family are encoded by 15 serine protease genes clustered at chromosome 19q13.4. Our Northern blot analysis of 19 normal human tissues for expression of KLK4 to KLK15 identified pancreas as a common express...
متن کاملOld genes and new genes: the evolution of the kallikrein locus.
The human kallikrein locus consists of KLK1, the gene of major tissue kallikrein, and 14 genes of kallikrein-related peptidases (KLKs) located in tandem on chromosome 19q13.3-13.4. In this review, based on information retrieved from the literature or extracted from genome databases, it is hypothesised that the kallikrein locus is unique to mammals. The majority of genes are highly conserved, as...
متن کاملUsing kallikrein-related peptidases (KLK) as novel cancer biomarkers.
Thromb Haemost 2009; 101: 222–224 The scientist Emil-Karl Frey, a scholar of the famous surgeon ‘Geheimrat’ Ferdinand Sauerbruch, observed in 1925 a considerable reduction in arterial blood pressure when he injected human urine into dogs, an until then unknown cardioactive and vasoactive effect which he attributed to an unspecified substance with potential biological functions (1, 2). This then...
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The tissue kallikrein-related peptidase family (KLK) is a group of trypsin- and chymotrypsin-like serine proteases that share a similar homology to parent tissue kallikrein (KLK1). KLK1 is identified in heart and has anti-hypertrophic effects. However, whether other KLK family members play a role in regulating cardiac function remains unknown. In the present study, we demonstrated for the first...
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